Manuel Madeira

PhD student in Artificial Intelligence at EPFL, advised by Pascal Frossard and Dorina Thanou

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My research focuses on the interplay between generative models, in particular diffusion and flow matching, and data structure, often using graph generation and language modeling as testbeds. I explore both how these models exploit inherent data structure and how to explicitly encode this structure into them. I also apply these methods to scientific problems, including molecular generation and digital pathology.

During my PhD, I interned at Apple MLR, where I investigated training-inference alignment in masked diffusion language models, and at Amazon, where I developed graph-based deep learning methods for supply-chain planning. Before starting my PhD, I was a Machine Learning Researcher at Inductiva, a startup where I worked on physics-informed neural networks for heat diffusion and coastal dynamics.

Prior to that, I completed my BSc and MSc in Biomedical Engineering from Instituto Superior Técnico. I was also a visiting student at Tsinghua University. For my MSc thesis, I worked on variance reduction for stochastic convex optimization with Renato Negrinho, Pedro Aguiar, and João Xavier.

For a complete list of publications, check my Google Scholar page.

Selected Publications

  1. trajectory_aware_preview.png
    On Trajectory-Aware Training for Masked Diffusion Language Models
    Manuel Madeira, Amitis Shidani, Alice Bizeul, and 6 more authors
    arXiv, 2026
  2. defog_thumbnail.png
    DeFoG: Discrete Flow Matching for Graph Generation
    Yiming Qin*, Manuel Madeira*, Dorina Thanou, and 1 more author
    ICML, 2025
    Oral Presentation
  3. construct_website_thumbnail.png
    Generative Modelling of Structurally Constrained Graphs
    Manuel Madeira, Clément Vignac, Dorina Thanou, and 1 more author
    NeurIPS, 2024